Oxford Professor Says Mankind Is Ethically Obligated To Create Genetically Engineered Babies
from the pick-and-choose dept
As we were just talking about the appeals court ruling that isolated genes are still patentable, we will have to begin thinking about how such a ruling will impact our lives. Some groups have decided to go the property rights route to assign ownership of DNA. Others wring their hands over how this will impact medicine. But, now that testing for genetic markers in embryos is in vogue, we can finally ask "what about the children?"The Telegraph put that question to Professor Julian Savulescu, expert in practical ethics at Oxford, and he states, unequivocally, that not only should the genetic testing of embryos for physical illnesses be allowed, but applying those same tests for behavioral genetic markers is mankind's ethical obligation. It should be noted that, currently, outside of a few accepted tests these screenings are illegal, but Savulescu thinks that needs to change.
"Surely trying to ensure that your children have the best, or a good enough, opportunity for a great life is responsible parenting?" wrote Prof Savulescu, the Uehiro Professor in practical ethics. "So where genetic selection aims to bring out a trait that clearly benefits an individual and society, we should allow parents the choice."There is a word for this kind of mass-screening, one which you won't hear Savulescu utter, and it is called eugenics. The reason many advocates of this kind of screening won't use that word is because it long ago became associated with Nazi philosophy, even though (as you can read in the Wiki article) many other nations did and still do some flavor of eugenics. The United States, for example, has some jurisdictions where testing for diseases (mostly STDs) that could be passed along to children is a requirement prior to attaining a marriage license. Israel has a program called Dor Yeshorim that tests for a multitude of hereditary diseases like Tay-Sachs and Cystic fibrosis. In China, eugenics has taken a more prominent role, with the PRC's Marriage Law requiring a doctor's approval prior to marriage (harsher language against specific illnesses found in previous iterations of the law have been removed over the years).
But what is different about Savulescu's argument is that we are no longer talking about genetic illnesses in the traditional sense, but instead behavioral genetic markers.
"Indeed, when it comes to screening out personality flaws, such as potential alcoholism, psychopathy and disposition to violence, you could argue that people have a moral obligation to select ethically better children. They are, after all, less likely to harm themselves and others."This seems to me to be a gross-oversimplification of the role genetics plays in behavior. While we can all spend the next few weeks in a long-form discussion of whether nature or nurture plays the predominant role in behavioral outcomes of children, I think few would disagree that both are aspects that do in fact play some role. And, while Savulescu seems to make his argument matter-of-factly, other bioethicists disagree. Predictably, many of these criticisms focus on Nazi eugenics to extrapolate the entire field, but not all of them.
Biologists, for instance, point to what occurs in small, isolated populations (i.e. the Dodo bird) when a lack of genetic diversity leads directly to a species extinction. They then point out that the combination of allowing for "designer babies" based on widely accepted culturally preferred traits and the perhaps inevitable monoculture that would result would breed a scenario in which mankind was ripe for massive exposure to a single disease.
Add to all of this the potential for inherent socio-economic lines to be drawn in the sand in terms of health, between those that can afford the testing for what are now patentable isolated genes and those that cannot, and you can see where potential abuse and negative consequences loom around every corner.
That said, I refuse to take a luddite approach to genetic testing in general, or even eugenics as a whole. I admit that I write this entire piece without fully understanding where I stand on the issue, aside from what I think is the rather common sense position of advocating caution. Instead, I open the topic to you, the reader, for the comments section.
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Filed Under: babies, ethics, gattaca, genetic engineering, traits
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Not yet slippery
I agree that once this crosses over into "construction" of human beings with arbitrary genes, then you will have moral problem. But I cannot see the big deal about letting people screen for diseases, since that still requires a traditional mixture of two individuals' DNA - thus alleviating any concerns about "monocultures". Indeed, I would consider it a moral obligation to a potential child. Since humans no longer feel the effects of natural selection - even the weakest among us can survive - then we ought to begin some form of artificial selection to pick up the slack.
Of course, humans won't just stop making babies the natural way if this was possible. Honestly, in the end, I think this could be a boon to evolution; a shot in the arm, so to speak. These new screened humans would still compete with the home-grown kind, and could very well lead to selective sweeps much faster and with less suffering than "traditional" evolution.
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Re: Not yet slippery
As I said, I don't have a fully formed opinion yet, but here's where the problem might lie. Whether we're talking about disease, as you were, or behavioral gene selection, as the article discussed, some of the same genes that put you at risk for one disease also ward off another. I'll have to go hunting for the link I was reading when writing this if you want a citation (if you really want me to, I'll go find it), but that was one of the biologists' problems: unintended consequences.
Sure, we could eradicate every genetic marker for Alzheimer's through unnatural selection, but what if that same gene protects against some far WORSE disease that then runs rampant across the entire population?
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Re: Re: Not yet slippery
I think of natural selection as the free market for valuing genes (and vice versa). Planned genomes are about as likely to work well long term as planned economies. We just don't know enough.
And "designer babies" doesn't require building up chromosomes from scratch. You can easily converge on a monoculture just by being highly selective about which embryos are allowed to develop.
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Re: Re: Re: Not yet slippery
You could, but remember that this form of selection isn't exactly trivial. It takes an embryo, and it's not like you can easily generate hundreds of embryos and choose between them. See the random number generator example below.
I think what you'd see is that most people would select the first embryo that didn't have any debilitating diseases or massive risk factors, like triple chromosomes.
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Re: Re: Re: Re: Not yet slippery
Consider how the Human Genome Project went from a massive, billion dollar, decades long project to being something you can whip out in a few weeks with the right equipment. In the not-too-distant future, having your whole personal genome sequenced will be routine medical procedure.
It's not hard to imagine that the ability to artificially produce and then screen zygotes could accelerate rapidly, especially if say, I don't know, there were people willing to pay lots of money for it. Of course, mixing and matching the desired genes up front might be easier.
Either way, we're going to have to deal with the issue and its consequences.
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Re: Re: Re: Re: Re: Not yet slippery
However, there are very real limits to the number of eggs a woman can safely produce in a given time, unless you start farming eggs from lots of women at the same time or give them some potentially nasty drug that makes them produce lots of eggs.
And even if people were willing to pay lots of money for it, not everyone has lots of money, so the danger of monoculture humans then depends on this technology becoming so cheap that even those in poverty can afford it.
Screening consecutive embryos for the first one that lacks major risk factors, IMO, does not cross the line. Creating arbitrary genetic sequences, IMO, does cross the line. I am inclined to say that making "embryo factories" to manufacture lots of potential embryos so that we may be highly selective is more likely to cross the line than not.
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Re: Re: Re: Re: Re: Re: Not yet slippery
Or you discover a way to induce progenitor cells to divide into viable eggs in a test tube. Who knows what will be possible In the Future(tm).
And even if people were willing to pay lots of money for it, not everyone has lots of money, so the danger of monoculture humans then depends on this technology becoming so cheap that even those in poverty can afford it.
You just need lots of money to get the ball rolling. Twenty years later it's routine clinic procedure if enough people want it.
Screening consecutive embryos for the first one that lacks major risk factors, IMO, does not cross the line. Creating arbitrary genetic sequences, IMO, does cross the line. I am inclined to say that making "embryo factories" to manufacture lots of potential embryos so that we may be highly selective is more likely to cross the line than not.
IMO, there's not that much of a line there. We already screen for many things unambiguously viewed as "defects" (fatal diseases) in IVF and pregnancy. Technology will only make this easier, one way or another, whether the actual process involves making lots of embryos and picking the one you want or just making one with genes you pick. Either way, the risk of monocultural vulnerability and other unintended consequences is there. As other commenters have said, I do think this is inevitable. I just also think it's pretty scary.
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Re: Re: Re: Re: Re: Re: Re: Not yet slippery
I still think concerns for monoculture vulnerability are overblown. Not one person has addressed my point that people will still make babies the old fashioned way, the least of which would be every single unintended pregnancy.
Even in the Future(tm) where this is cheap and easy for everyone, short of actual designer babies made of arbitrary DNA sequences, I still don't see a cause for concern regarding monoculture vulnerability. Certainly some people would sift through hundreds of embryos for the perfect child, but consider how many people are vehemently against abortion. I find it hard to believe that the majority would want to screen hundreds of embryos.
When in doubt, you could always enforce good old government regulations. Society could make it illegal to make hundreds of embryos, instead setting a quota like "you can try up to 10 embryos per year" or something.
Without mandatory enforcement, and without creating arbitrary DNA sequences, and without the shotgun approach (i.e. make hundreds and pick the "best"), I really do not see the concern with monoculture vulnerability.
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Re: Re: Re: Re: Re: Re: Re: Re: Not yet slippery
Two things:
1) We already screen natural pregnancies (intended or otherwise) for various genetic defects during the first trimester using tests like amniocentesis and its more modern cousins. Expect this to increase.
2) Random pairings don't increase genetic diversity if the partners are drawn from an increasingly homogeneous gene pool. If a significant fraction of the babies born had chosen "designer genes" they're still going to pass on those genes to their natural offspring.
I don't think anyone is saying the whole population will become smiling Stepford clones overnight, but the more we gain the ability to choose the genes of our children, the more they will converge over time toward a small "desirable" pool.
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Re: Re: Re: Re: Re: Re: Not yet slippery
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Re: Re: Re: Not yet slippery
Having said that, I get your point that just finding the 'bad' genes and getting rid of them is not that simple.
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Re: Re: Re: Re: Not yet slippery
However, I think some people imagine the rush to get rid of all "bad" genes is overblown. I'm actually afraid you'd have the opposite problem - people would *want* their child to be a carrier for genes like this one.
But then you have a load of people who are carriers, and if enough people are carriers, you might actually see increased prevalence of the full-blown recessive disease. Remember, just because this technology exists doesn't mean there won't be old-fashioned babies.
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Re: Re: Not yet slippery
I think you also overestimate how effective this technique is. Sure, you could TRY to eliminate every risk factor for Alzheimers. But remember, you gotta make an embryo for each trial.
Imagine the embryo is a random number, and we have a random number generator. It generates a number that has 20 digits. Pretend the numbers 3, 5, and 7 give you Alzheimers, but 7 is the least likely risk factor.
How many times would you have to generate a random 20 digit number before it didn't contain any 3s, 5s, and 7s? I'm not inclined to stats but I'm willing to bet it's pretty hard and probably cost-prohibitive when it comes to creating embryos. But what if you generated a number with no 3s and 5s, but a 7 was there. You could choose to take your chances with that one, but if you didn't you might never get a number without 3s and 5s...
And again, humans will still make babies the traditional way (at least every unintended pregnancy would be a traditional baby). There is very little risk of having monoculture humans, where a disease can run rampant through the *entire* population. These "screener babies" would still compete with the old fashioned kind, and again they wouldn't be designed from scratch.
Now, if you were designing arbitrary genetic sequences...yes, that crosses the line and you start sliding down the slippery slope into danger.
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Re: Re: Re: Not yet slippery
They kind of have a point though. I mean, if you're going to bother raising one, why gamble when your kid could have perfect speed.
Speaking of which, since I guess it's still-sort-of-topical, if these theoretical kids grow up to be great athletes, do we let them compete in the Olympics, or are they relegated to their own separate competition? Because then it really would be Pokémon.
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Re: Re: Not yet slippery
For instance:
http://www.cdc.gov/malaria/about/biology/sickle_cell.html
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Re: Re: Not yet slippery
Intelligent, good looking, thin, disease free people. I like those unintended consequences.
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Re: Re: Re: Not yet slippery
Is this a joke? You do realize that those are the intended consequences, right? The unintended ones...potentially not so nice.
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Re: Re: Re: Re: Not yet slippery
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Re: Re: Re: Re: Re: Not yet slippery
No, what it means is that lots of other comments (and the original article) have already mentioned the well known risks of monoculture so I felt no need to rehash them.
I was, in fact, seriously asking if this was a joke I didn't get since it seems to misunderstand what "unintended consequences" means. Silly me.
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Re: Re: Re: Re: Re: Re: Not yet slippery
Wow... I never thought that I'll have a chance to say this.
Let's cut the guy some slack. Given that he was thrown down a mountain by his mother for being born with a birth defect in his leg, this definitely looks like an undeniably attractive option to him.
And yes, this is intended as a joke, Hephaestus.
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Re: Re: Not yet slippery
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Re: Re: Not yet slippery
I think this would be the case if our species made this testing mandatory. If we leave it up to choice to the parents then I don't see it being an issue, as there will always be people who'll refuse to get the testing done, which will ensure natural selection breeding is still occurring in the wild.
There will always be worse diseases out there whether your genetically modified or not, I almost think its a moot argument.
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Also
But if you were a carrier for Tay-Sachs and so was your partner, wouldn't you want to screen your embryos to make sure you don't get a baby with full-blown Tay-Sachs?
Also, this is not designer babies. That would be creating wholly synthetic DNA from scratch. This still involves the use of good old fashioned sperm impregnating egg.
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Re: Also
It would appear the definition for Eugenics isn't as narrow as you make it sound...
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Re: Re: Also
"the study of or belief in the possibility of improving the qualities of the human species or a human population, especially by such means as discouraging reproduction by persons having genetic defects or presumed to have inheritable undesirable traits (negative eugenics) or encouraging reproduction by persons presumed to have inheritable desirable traits (positive eugenics)."
"the study of methods of improving the quality of the human race, esp by selective breeding"
"The study of hereditary improvement of the human race by controlled selective breeding."
It seems that selective breeding is a common theme in eugenics. And of course we must contend with the colloquial definition, which tends to be "sterilize people we don't like".
While the proposed method might qualify under a broad definition of eugenics, it is a particularly prejudicial term that predisposes the reader toward faulty assumptions.
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Re: Re: Re: Also
Yup, which I mentioned in the article to combat those faulty assumptions :)
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Re: Re: Re: Also
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Re: Not yet slippery
If you're talking about terminating the proto-people (embryo, fetus, what-have-you) that don't appear up to snuff, I think that there's a pretty solid moral/ethical counterweight.
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Re: Re: Not yet slippery
I would also be interested in your opinion regarding the discarded embryos from IVF. Do they represent a moral or ethical counterweight to the IVF technique?
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Re: Re: Re: Not yet slippery
Having said that, the bible does have something to say on this matter which most people don't realize or ignore.
Leviticus 17:11
For the life of a creature is in the blood...
Maybe this has some bearing on the ethical portion of things when it comes to ebryos.
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Re: Re: Re: Re: Not yet slippery
So if you want to quote Leviticus as the basis for any decision, I hope you don't eat any shrimp.
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Re: Re: Re: Re: Not yet slippery
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Re: Re: Re: Not yet slippery
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Re: Re: Re: Re: Not yet slippery
On that note, I agree with you entirely. In fact, I think that's one of the main reasons that you won't have people making hundreds of embryos and then selecting the best one. I honestly think the majority would accept the first child that was clear of all major known risk factors, regardless of their hair color, eye color, height, etc. I know I certainly would not want to create any more embryos than necessary in order to have one which will lead to a healthy child.
In fact, that's one of my primary arguments against this leading to monoculture vulnerability. I just don't see the majority exercising excessive selective pressure on their offspring. As you say, one's own ethical and moral principles would probably weigh heavily against "farming" embryos, so that they are happy with the first viable, healthy one.
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Re: Re: Re: Re: Not yet slippery
Ah, so that's why the newts are rushing to multiple marriages?
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Re: Not yet slippery
Letting? I have no problem with that. Mandating? That's different.
The problem is that the last time we slid down this slippery slope was pretty extreme and still within people's living memories. It was only a few decades ago that Oregon, for instance, stopped forcing people with certain genetic diseases to be sterilized. And only a few years ago that they apologized for it.
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Re: Re: Not yet slippery
That said, I find it disingenuous to compare screening with sterilization. These things are quite different, since screening still allows those with genetic diseases to make offspring. In fact, I dare say this would make it easier for those people to have offspring, safe in the knowledge that their child will not suffer the way they do.
As a society, we need to have an honest discussion about what is acceptable and unacceptable, and freaking out about some fucked up shit someone else did in the past is no reason to throw the baby out with the bathwater. It is little different from those people who freak out about nuclear power plants because of Three Mile Island or Chernobyl. It impedes progress when we let the ghosts of the past prevent rational discussion in the present, and it enables those at the fringe of society to take things further in the dark than society would otherwise find acceptable.
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Re:
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Science Fiction
A species genetically engineers a yeast-style organism that will act as a contraceptive. Unfortunately, the yeast causes complete infertility after a few generations. Since the species failed to limit the changes in a contained experimental area, their entire population is wiped out.
This can obviously be extrapolated to the human population. If we experiment with things like trait selection, we could end up wiping ourselves out because of problems we don't foresee. It would be nice if we'd perform our genetic experiments (with ourselves, our food supply, diseases) in a way that they couldn't completely destroy our species.
No, I'm not a luddite. But we shouldn't turn future humans into bananas, just waiting for a well-suited plague to kill us all.
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genetic engineering
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Why not have government-mandated genes to create 'good citizens'? /sarcasm
And who decides what constitutes 'ethical' behaviour anyway?
Far too many counter-cultures and social trends would have been thought ill of when they started.
No wonder other other biologists disagree, the limited genes could produce rapid progression of diseases through a genetically similar population.
I am also taking the luddite approach since I am not sure that people could properly gauge the full impact of these changes without a massive long-term study over a host of generations to look possible problems.
And what about the impact of the parents environment on the expressed genes within their children?
The whole thing is far-fetched at this stage.
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Implanting good genes? If "good genes" means your future kid won't throw a good curve ball, I disagree. If "good genes" means modifying your future kid to get rid of that upcoming Alzheimer's, then I say it is the parents' choice.
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and dare i say
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Re: and dare i say
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Alternative headline
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Familiar
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Opposing view
I don't feel like weighing in because it's really tough and my comment would take up way too much space on this page.
I would recommend, however, that if you're looking for a counter argument check out Professor Michael Sandel from Harvard. There are probably YouTube videos where he discusses exactly this. I read an abstract of a paper by him once. Sorry...don't have a link... :(
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MEH.
that is all.
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Presumption
The moment we destroy an embryo is the moment we destroy the awesome potential of a human being. It is just plain presumptive wild guessing to say what value a person might have based on segments of his DNA.
Further, I have yet to meet a perfect person. If we select for people with no potential for behavioral defects, we won't get to select anybody.
The only right choice is to let each individual discover his potential and all help each other to achieve the best we can be, regardless of what is "right" or "wrong" with each one of us.
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Re: Presumption
No really, everyone should see it. Great movie.
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Re: Re: Presumption
No such thing.
Is there a book?
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But my understanding is that he's talking about terminating Child X if s/he demonstrates A, B, or C trait-related genes, in the hope that Child X1 will not.
That's a very different ethical/moral question.
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just no...
"It's like saying you need a record to be-bop, I don't NEED a record!!"
I do not agree with any level of DNA temperament. Most of the diseases being talked about or causing problems in the past and foreseeable years are do to POOR DIETS. America eats shit and our bodies react in kind. SO instead of being lazy and ignorant(genetics won't fix that, btw), education is your answer. Wow, another thing that blows donkey bawls in America.
Genetics means nothing to a persons future, prone to these "problems" does not mean you have to create and assist the problem. Own up to the choices you make and lets not create people who have no repercussions of their choices and just help them prevent instead of messing with things out of scope. It's a quick dirty fix and like any other quick dirty fix it will be short lived.
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Not to mention solving old age would be one of the possibilities.
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goodbye art
no more alcoholic traits? - goodbye Dlyan Thomas
no more depression traits? - goodbye Van Gogh
no more propensity for deafness? - goodbye Mozart, Beethoven
The mark of a society is more about the ability for it to absorb and develop its differences, not eliminate of them. I see nothing wrong with the recognition that a person is born with a behavioral marker, but the person should not then be saddled with the expectation of marker appearance, let alone be removed from the gene pool on the off chance.
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genetic modification isn't new
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Gattaca! Gattaca!
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Re: Gattaca! Gattaca!
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in short
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Re: in short
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Flash: Professor utterly clueless about the real world
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Re: Flash: Professor utterly clueless about the real world
It's also clear to me that this idiot has not done his homework on the pure biological facts of what he is pontificating on.
Given the serious consequences of his ideas taking root, this is not something an ethical person would spout off about without first acquiring the requisiste factual knowledge to ensure they are not advocating something that is in reality dangerously dellusional.
On the basis of his performance, I award this professor an F grade on his ethics and an F grade on his academic intregrity.
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Let's do it...
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Re: Let's do it...
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Re: Re: Let's do it...
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No time!
I am creating new isolated genes.
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Re:
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the problem: is nutters are useful?
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Re: the problem: is nutters are useful?
Utopian visions aside, any society that did this on a large scale probably wouldn't exist very long if its belligerent neighbors didn't.
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Re: Re: the problem: is nutters are useful?
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Re: Re: Re: the problem: is nutters are useful?
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Re: Re: Re: the problem: is nutters are useful?
Anyway, it would be interesting to see, perhaps, what parents would choose to have in a kid, if they could. For example, maybe weaker-willed, frail parents would choose to live vicariously through their offspring?
It's a shame there's such a taboo on the whole subject.
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Re: Re: Re: the problem: is nutters are useful?
Years later I read an article about a genetic error in the human chromosome when we split from the common ancester which means human muscles are only 25% the strength of any other primate species, and it suddenly made sense.
Not looking forward to a future in which a select few have that genetic flaw fixed, and are four times as strong as the rest of us poor bastards.
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Re: Re: Re: the problem: is nutters are useful?
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[random, nonsensical personal attack about this view being applied to Tim/Mike's parents altering the course of their lives]
It would be so nice if everyone believed what you do because then you and this site wouldn't exist!
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Uhm...
Innovation of the sort that produces our greatest advancements is almost certainly "outside of the norm".
Humanity needs those oddballs and their "abnormal" genes, and we need to make sure our culture supports them well enough that they can avoid poor expressions. What we really have is a poor support culture.
The underlying theme of this is that because our society fails to properly help people be better members, regardless of their underlying genetic makeup, we need to normalize everyone's genes. It's like saying we should make all buildings short, because tall buildings are dangerous...
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Someone raised with and believing in Sharia law will have a very different definition of either of those things than someone raised as a strict-construction constitutionalist. Both will have a radically different definition than a radical ultra-far-left liberal.
Or does the professor want to engineer people who can't buck the system, whatever that system might be? You think we have a sheeple problem NOW? People like that will set the status quo into steel-reinforced mil-spec concrete. Good or bad, the way things are when THAT mod becomes widespread will be the way they'll be ten thousand years later. I hope for our sakes, if not the countless generations ahead, that society and the systems supporting it are perfect when that mod is applied, because if not...
Is enacting a real life version of Idiocracy, with stupidity replaced with conformity really all that great an idea?
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Why not?
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Re: Why not?
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Re: Why not?
The kind of person that would abort a baby just because they want to abort a baby is the kind of person that should not be having a baby anyway. So on the face of it, although I suspect quite strongly you are attempting grim sarcasm, I agree with your sentiment: if a parent wants to abort because a known genetic deficiency is found, that decision should be between themselves and their doctor.
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Coordinator-like children?
Just don't turn this into a Racial war.
We don't really need THAT kind of junk around.
Humans are still Humans, no matter how they are born as long as they still have their humanity and their human heart.
Granted, this will be a boon for those geneticist and other doctors who wish to see if they can modify a human being before it was conceive.
But the question is WILL those DOCTORS will be still humane enough to treat the "Coordinator"(yes. I'm Using GS/GSD term) like a normal human being? Or pull a Hojo(A VERY immoral scientist from Final Fantasy VII, who treats nearly every test subjects as expendable Object/Guinea pigs, even to his wife(Lucrecia) and son(Sephiroth).) and treat them just like an object or Guinea pig that can be killed/thrown away when their usefulness is over.
What? Sometimes, those anime and/or games got some lesson you can appreciate and can be applied to real life, as long you understand their story and the characters' background.
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Shrinking the gene pool
This, however, will lead to stagnation in the gene pool. There is a reason why the human race is so diverse. With diversity comes strength, the ability to adapt and change. If everyone was the same, the genes needed to adapt to future situations would not be there. Evolution (micro or macro) would come to a dead stop.
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It's a step in the right direction and I'm sure someday we will have technology that we will never even begin to dream of in our lifetime.
I'm also sure they'd look back at us like the bunch of wild animals we are lol.
Well maybe not we'll probably blow ourselves up first in our conquest for global domination.
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The only way for a government not to practice mandatory eugenics is to let the people do what they want with their own genetic material.
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Headline vs Content
Content: "When it comes to screening out personality flaws, such as potential alcoholism, psychopathy and disposition to violence, you could argue that people have a moral obligation to select ethically better children." (Emphasis added)
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This is basically what some old civilizations (such as the Greek) did with their malformed babies. Kill them. Except that now you can see those malformations on the DNA level and we all know how subjective "bad behavior" can be.
Maybe you can engineer a baby to fix a disease but even that has its consequences.
Malaria cannot develop on ppl with certain blood related genetic diseases (that only manifest if there are two dominant genes) so you are messing with a gene that may actually be a good thing. We are being too damn arrogant if we think we can actually grasp a gene in a systemic way (ie: know exactly everything it affects in the organism).
Again, no. Get rid of that idea.
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As an example, various mental illnesses have been correlated to creative and artistic talent, and to high intelligence.
Lower IQs are associated with pleasant things like being happier.
Being more dellusional is correlated with happiness, being realistic is correlated with higher rates of unhappiness.
So which we do wipe out? Dellusional folk or unhappy folk? By whose standards do we decide whether increased risk of creative talent is not worth increased risk of mental/emotional/psychiatric (and associated behavioural) pathology?
Wouldn't it make more sense to return to the more progressive notion of working on the environment and ask what needs to change about society to accommodate humans best, instead of this notion where we consider how we can force humans to fit the higgeldy piggedly state of a particular society at a particular time?
No matter what we do with the DNA, pathological environments will always result in higher rates of pathology, and healthy environments will always generate lower rates of pathology. Most people, regardless of DNA, do poorly in a pathological envirnment, and that most people, regardless of DNA, do well in a healthy environment.
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The Last Word
“Let's do it...
So who's going to be the first to file a business method patent on makin' babies?